Fruits that are grown on the ground, such as watermelon or cantaloupe, have been found to have a high risk of causing foodborne illness. This is mainly due to a pathogenic bacterium called Listeria, which may develop on the rind and spread onto the edible parts when cutting the peel.
In the U.S., between 1974 and 2011, there were 35 reported cases of food poisoning linked with the consumption of melons. This resulted in 3,603 cases of illness, 323 hospitalizations and 45 deaths, so it’s definitely not something to overlook.
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